At Duke Kunshan University, each major consists of an interdisciplinary set of courses that integrate different forms of knowledge and a distinct set of disciplinary courses that provide expertise in specific areas.

Undergraduate students will declare their majors before the end of their second year. Duke Kunshan initially offers 8 majors approved by the Chinese Ministry of Education, and more majors are under development, including humanities majors that integrate history, philosophy, literature, and the arts, as well as social science majors integrating economics, sociology, anthropology, and psychology. By the time the inaugural class of students declare their majors in 2020, there will be close to 20 majors.

The first round of approved majors include:

In addition to the initial 8 majors listed above, more majors are under development. The new majors that have been submitted to the Chinese Ministry of Education for approval include: